Lowering of cholesterol level in the blood serum of rabbits by halogen substituted salicylhydroxamic acids.

It lias formerly been shown by C z y ż y k and U r ­ b a ń s k i [4] that 5-bromosal icylhydroxamic CONHOII acid (BSH) in some cl inical cases signifiL cantly reduced the cholesterol-level in / ip* blood serum. T h e choice of B S H for these I I B S I I experiments was based on the fact observB r ^ ^ / ed b y J o h n s o n , M a n к i e w i с z et al. [8] that B S H was proved to be (in cl inical experiments) an effective inhibitor of isoniazide inactivation, which in turn is the result of N-acetylation of isoniazide [7], and on the other hand it is wel l known that acetic acid is the precursor of cholesterol in the rat [2], and the biosyn­ thesis of cholesterol can start from acetate [1, 16].